Principal Scientist, LNP Drug Product Characterization (Biophysics and Analytics) - Vaccines (Waltham) Job at 卡湯晩, Waltham, MA

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  • 卡湯晩
  • Waltham, MA

Job Description

Job title: Principal Scientist, LNP Drug Product Characterization (Biophysics and Analytical) - Vaccines

Location:

Waltham, MA

About the role

As the Principal Scientist within the Drug Product Platform and Early Clinical Development Team, you will provide hands-on leadership to a small team focusing on LNP analytics to characterize LNP Drug Products. Your responsibilities include method transfer, team development, cross-functional collaboration, and supporting the development of new LNP formulations for mRNA vaccines.

Main Responsibilities:

  1. Build and lead a team (1-2 contractors) for biophysical characterization and analytical needs.
  2. Coordinate with Analytical Science to ensure method alignment and improvements.
  3. Develop testing strategies, including sample tracking and data reporting.
  4. Collaborate on biophysical characterization studies to support new LNP platform development.
  5. Mentor junior scientists and manage analytical operations.
  6. Provide scientific insights into particle size, zeta potential, morphology, and other biophysical properties.
  7. Support technology transfer to toxicology and pilot scale.
  8. Participate in cross-functional teams for mRNA vaccine development.
  9. Analyze data, prepare reports, and stay current with literature.
  10. Recommend equipment and provide training and guidance to team members.

Qualifications:

  • Ph.D. in Biophysics, Physics, Chemical Engineering, or related field with 3+ years of experience.
  • Knowledge of nucleic acids, lipid biochemistry, and drug product process development.
  • Experience with biophysical characterization of lipid nanoparticles.
  • Proficiency with analytical tools like SEC, DLS, HPLC, microscopy, etc.
  • Leadership experience is preferred.
  • Strong communication, organizational, and problem-solving skills.

Why Join Us?

  • Opportunity to work on innovative mRNA vaccines.
  • Career growth and development opportunities.
  • Comprehensive health and wellbeing benefits.

Sanofi is an Equal Opportunity employer committed to diversity and inclusion. We welcome all qualified applicants to apply.

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Job Tags

Full time, For contractors,

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